Dr. Clifton Franklund

Professor of BiologyFranklund
Biology Program Coordinator
Office: ASC 2011
Phone: (231) 591-2552
E-mail Address: franklc@ferris.edu



Ph.D. in Microbiology and Immunology,  Medical College of Virginia, Richmond, VA
M.S. in Bacteriology,  North Dakota State University, Fargo, ND
B.A. in Biology, Concordia College, Moorhead, MN


Areas of Specialization:

Bacterial physiology, microbial genetics, microbial pathogenesis, immunology, bioinformatics, computer programming, online learning, and assessment


Courses Taught at Ferris State University:

BIOL 108: Medical Microbiology

BIOL 286: General Microbiology

BIOL 387: Microbiology and Immunology


Research Interests:

Lipopolysaccharide (LPS) is known to play a variety of important roles in the virulence of Gram-negative bacteria. It has been implicated in processes as diverse as attachment to host tissues, evasion of phagocytosis, molecular mimicry, and (most importantly) immune stimulation. Periodontal disease is the result of a chronic host inflammatory response to oral bacteria. One of the most commonly isolated microbes from the gingiva is the Gram-negative anaerobe, Fusobacterium nucleatum. Given the predominance of F. nucleatum in oral infections, it seems logical to test the role of its LPS in promoting the inflammatory response observed in advance periodontal disease. From the literature, it is clear that LPS, proteinaceous virulence factors, metabolic end products, and host factors all contribute to the tissue damage seen in periodontal disease. Furthermore, in many cases these factors may perform the same or similar functions. The complexity of this clinical situation makes it very difficult to determine causal relationships between bacterial species, their products, and tissue damage. My research is focused upon establishing an experimental system to explore the structure, function, and diversity of LPS in F. nucleatum. I am also interested in using Caenorhabditis elegans as a model for studying bacterial pathogenesis in vivo. For more information on these and other microbiology-related projects, please seek out Dr. Franklund.


Awards and Achievements:

Award for an exemplary online course (web enhanced) - 2007


Selected Publications and Presentations:

1) Franklund, C.V. Using Computer-Assisted Formative Feedback to Enhance Learning in an Introductory-Level Microbiology Course. Lilly Conference on College and University Teaching. 2008.

2) Nolan, D., H. Abdelhadi, and C.V. Franklund. Cloning and Characterization of the recA Gene from Fusobacterium nucleatum 10953. National Meeting of the American Society for Microbiology. 2003.

3) Raps, A., and C.V. Franklund. Cloning and Analysis of a Lipopolysaccharide Core Gene from Fusobacterium nucleatum. National Meeting of the American Society for Microbiology. 2002.

4) Pandak, W.M., P. Bohdan, C. Franklund, D.H. Mallonee, G. Eggertsen, I. Björkhem, Z.R. Vlahcevic, and P.B. Hylemon. Expression of Sterol 12a-Hydroxylase Alters Bile Acid Pool Composition in Primary Rat Hepatocytes and In Vivo. Gastroenterology 120:1801-9 (2001).

5) Raps, A., and C.V. Franklund. Cloning and Analysis of a Lipopolysaccharide Core Gene from Fusobacterium nucleatum. Southern California Branch Meeting of the American Society for Microbiology. 2001.


Websites of Interest:

Dr. Franklund's homepage - I have created this site ot provide more information about me, my education, and my interests in and outside of academia.

My online calendar - A Google calendar of my teaching and administrative duties is embedded in this web page.

Small things considered - Dr. Schaechter's blog covers the width and depth of the unique microbial activities on this planet.

MicrobeWorld - A website supported by the American Society for Microbiology covering all things microbial.

Bacterial genomes - An exhaustive list of genomic information currently available for prokaryotes from the European Bioinformatics Institute.

Delicious tags - I am working to update all my favorite websites into my delicious tags.


Joined Ferris State University: Fall 2006