Dr. Changqi Zhu

Associate Professor of BiologyZhu
Office: ASC 2116
Phone: (231) 591-3196
E-mail Address: Zhuc@ferris.edu


Ph.D. in Molecular and Developmental Biology, The University of Karlsruhe, Germany
M.S. in Genetics, Northwest A & F University, China
B.S. in Biology, Shaanxi Normal University, China

Areas of Specialization:

Changqi C. Zhu specializes in molecular biology and developmental biology. His main research interest is to understand the molecular mechanisms underlying both vertebrate and invertebrate animal development. Over the last several years, he has identified the Groucho family co-repressors as the interacting proteins of homeodomain protein Six3 in mammalian eye development, and has studied the functional roles of Activin signaling in the larval brain lobes development and oogenesis of fruit flies (Drosophila melanogaster). His current research aims to identify the key molecular events regulating the longevity of fruit flies.

Courses Taught at Ferris State University:
BIOL 121
: General Biology
BIOL 370: Developmental Biology
BIOL 460: Current Topics in Biology

Awards and Achievements:
Ferris Faculty Research Award - 2010

Selected Publications:
1) Zhu CC, Boone JQ, Jensen PA, Hanna S, Podemski L, Locke J, Doe CQ, and O’Connor MB (2008). Drosophila Activin-b and the Activin-like product Dawdle function redundantly to regulate proliferation in the larval brain. Development 135, 513-521.

2) Zhu, CC*, Bornemann, DJ*, Zhitomirsky, D, Miller, EL, O’Connor, MB, and Simon, JA. Drosophila histone deacetylase-3 controls imaginal disc size through suppression of apoptosis. PLoS Genetics. 4(2), 1-11, 2008.

3) Lagutin, OV, Zhu, CC, Kobayashi, D, Topczewski, J, Shimamura, K, Puelles, L, Russell, HRC, McKinnon, PJ, Solnica-Krezel, L, and Oliver, G. 2003. Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development. Genes & Development 17, 368-379.
4) Zhu, CC, Dyer, MA, Lagutin, O, Uchikawa, M, Kondoh, H, and Oliver, G. 2002. Six3-mediated auto-repression and eye development requires its interaction with the Groucho family of corepressors. Development 129, 2835-2849.
5) Lagutin, O, Zhu, CC, Furuta, Y, Rowitch, DH, McMahon, AP, and Oliver, G. 2001. Six3 promotes the formation of ectopic optic vesicle-like structures in mouse embryos. Developmental Dynamics 221, 342-349.
6) Zhu, CC, Yamada, G, and Blum, M. 1999. Retinoic acid teratogenicity: the role of goosecoid and BMP-4. Cellular and Molecular Biology 45, 617-629
7) Zhu, CC, Yamada, G, Nakamura, S, Terashi, T, Schweickert, A, Blum, M. 1998. Malformation of trachea, and pelvic region in goosecoid mutant mice. Developmental Dynamics 211, 374-381
8) Alex, C, Zhu, CC, Cato, A, Blum, M, 1998. Expression of androgen receptor mRNA in mouse embryogenesis. Mechanism of Development 72, 175-178
9) Zhu, CC, Yamada, G, Blum, M. 1997. Correlation between loss of middle ear bones and altered goosecoid gene expression in the branchial region following retinoic acid treatment of mouse embryos in vivo. Biochemical and Biophysical Research Communications 235, 748-753