Dr. Changqi Zhu
Associate Professor of Biology
Office: ASC 2116
Phone: (231) 591-3196
E-mail Address: Zhuc@ferris.edu
Ph.D. in Molecular and Developmental Biology, The University of Karlsruhe, Germany
M.S. in Genetics, Northwest A & F University, China
B.S. in Biology, Shaanxi Normal University, China
Areas of Specialization:
Changqi C. Zhu specializes in molecular biology and developmental biology. His main research
interest is to understand the molecular mechanisms underlying both vertebrate and invertebrate
animal development. Over the last several years, he has identified the Groucho family
co-repressors as the interacting proteins of homeodomain protein Six3 in mammalian
eye development, and has studied the functional roles of Activin signaling in the
larval brain lobes development and oogenesis of fruit flies (Drosophila melanogaster).
His current research aims to identify the key molecular events regulating the longevity
of fruit flies.
Courses Taught at Ferris State University:
BIOL 121: General Biology
BIOL 370: Developmental Biology
BIOL 460: Current Topics in Biology
Awards and Achievements:
Ferris Faculty Research Award - 2010
1) Zhu CC, Boone JQ, Jensen PA, Hanna S, Podemski L, Locke J, Doe CQ, and O’Connor
MB (2008). Drosophila Activin-b and the Activin-like product Dawdle function redundantly
to regulate proliferation in the larval brain. Development 135, 513-521.
2) Zhu, CC*, Bornemann, DJ*, Zhitomirsky, D, Miller, EL, O’Connor, MB, and Simon,
JA. Drosophila histone deacetylase-3 controls imaginal disc size through suppression
of apoptosis. PLoS Genetics. 4(2), 1-11, 2008.
3) Lagutin, OV, Zhu, CC, Kobayashi, D, Topczewski, J, Shimamura, K, Puelles, L, Russell,
HRC, McKinnon, PJ, Solnica-Krezel, L, and Oliver, G. 2003. Six3 repression of Wnt
signaling in the anterior neuroectoderm is essential for vertebrate forebrain development.
Genes & Development 17, 368-379.
4) Zhu, CC, Dyer, MA, Lagutin, O, Uchikawa, M, Kondoh, H, and Oliver, G. 2002. Six3-mediated
auto-repression and eye development requires its interaction with the Groucho family
of corepressors. Development 129, 2835-2849.
5) Lagutin, O, Zhu, CC, Furuta, Y, Rowitch, DH, McMahon, AP, and Oliver, G. 2001.
Six3 promotes the formation of ectopic optic vesicle-like structures in mouse embryos.
Developmental Dynamics 221, 342-349.
6) Zhu, CC, Yamada, G, and Blum, M. 1999. Retinoic acid teratogenicity: the role of
goosecoid and BMP-4. Cellular and Molecular Biology 45, 617-629
7) Zhu, CC, Yamada, G, Nakamura, S, Terashi, T, Schweickert, A, Blum, M. 1998. Malformation of
trachea, and pelvic region in goosecoid mutant mice. Developmental Dynamics 211, 374-381
8) Alex, C, Zhu, CC, Cato, A, Blum, M, 1998. Expression of androgen receptor mRNA
in mouse embryogenesis. Mechanism of Development 72, 175-178
9) Zhu, CC, Yamada, G, Blum, M. 1997. Correlation between loss of middle ear bones
and altered goosecoid gene expression in the branchial region following retinoic acid
treatment of mouse embryos in vivo. Biochemical and Biophysical Research Communications